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KMID : 1145120210190040679
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Asian Journal of Beauty and Cosmetology
2021 Volume.19 No. 4 p.679 ~ p.692
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Anti-aging Effect of Mixed Extract from Medicinal Herbs
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Lee So-Youn
An Hong-Yan
Kim Woo-Soo
Jeon Hyang-Hwa
Park Han-Woong
Ha Jeong-Cheol
Cho Jin-Hun
Lu Xinxin
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Abstract
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Purpose : This study was conducted to confirm the applicability of a mixed herbal extract (MHE) as an anti-aging cosmetic ingredient by investigating its skin anti-aging activities in vitro and in vivo.
Methods : In this study, we prepared MHE using an ultrasonic extraction containing Forsythiae fructus, Tribuli fructus, Solomon’s seal, Siberian ginseng, Ponciri fructus and Ginseng. We investigated the anti-aging effect of the MHE for skin in dermal fibroblasts. The anti-aging activity was determined by the type I collagen synthesis levels. Matrix metalloproteinase-1 (MMP1) and tissue inhibitor of metalloproteinases 1 (TIMP1) mRNA levels were measured by qRT-PCR. MMP1 protein levels were evaluated by blotting analysis. Clinical tests of skin moisture, elasticity, texture, and wrinkles were performed using cosmetics containing 1% MHE.
Results : The MHE induced the upregulation of pro-collagen type I synthesis and TIMP1 mRNA expression. The MHE led to the downregulation of MMP1 mRNA levels and protein levels. Furthermore, after skin application of cosmetics containing 1% MHE, skin hydration, elasticity, texture, and crow’s feet were improved 4 weeks after the treatment.
Conclusion : MHE has an anti-aging effect by promoting collagen synthesis and suppressing MMP1 gene expression in vitro, and it has a skin improvement effect in vivo. Therefore, the MHE was shown to have value as a functional cosmetic ingredient.
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KEYWORD
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Skincare, Anti-aging, Anti-wrinkle, Natural cosmetics, Herbal medicine
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